SIST Journal of Pharmacy
type: channel
description: Types of Articles Research Articles Research articles are essential for disseminating the findings of original research studies. These manuscripts must detail the research methodology rigorously and provide a robust analysis of the results, contributing valuable insights to the field. Notably, systematic reviews can also be submitted as research articles, enriching the academic discourse on these critical topics. Review Articles A review article serves as a comprehensive overview of the existing literature in a specific subject area, synthesizing key findings and identifying trends that guide future research. This type of article is vital for researchers seeking to understand the landscape of a topic. Short Communications Short communications offer a dynamic platform for authors eager to share their results with the research community in a concise and impactful manner. This format ensures that important findings are rapidly communicated, fostering collaboration and innovation within the field. Letter to editor A Letter to the Editor serves as a powerful tool for readers to express their opinions, highlight important issues, and engage with current topics of public interest. Typically published in the "Letters to the Editor" section, these letters provide a platform for individuals to influence public discourse and raise awareness about vital matters in our communities. Mini-Reviews Mini-reviews provide a concise summary of a specific research topic or field relevant to Molecular Medicine. They put previous research and findings in context and present current developments in a critical and focused manner. Key aims of mini-reviews are to provide coverage of mature or emerging subjects, evaluations of progress in specified areas, and/or critical assessments of new technologies. Mini-reviews should be balanced and an excessive focus on the authors’ own work should be avoided. Mini-reviews should be no longer than 3,500 words, contain no more than two figures or tables, …
publisher: Sialscribe
language: en
publication name: SIST Journal of Pharmacy
copyright: Manuscripts must be submitted to this journal and not submitted or published elsewhere. The submitting author must secure approval from all co-authors for publication. Authors also permit editing for clarity. Direct any publication inquiries to Email
items: Assessment of Prevalence, Management and Attitude of dysmenorrhea among University students of Sialkot, Pakistan.
items: CORRELATION OF TRUNK CONTROL AND LOWER LIMB FUNCTIONAL MOBILITY AMONG CHILDREN WITH CEREBRAL PALSY
items: Assessing the Effect of Dietary Practices and Physical Activity on the Health of Pregnant Women
items: Quality and Microbial Assessment of Cooking Oils and Serving Plates Used by Street Food Vendors in District Sialkot, Pakistan
items: Assessment of Knowledge, Attitude, and Practices about the Management of Medication Errors among Healthcare Professionals in District Sialkot, Pakistan
items: Exploring the Role of Microneedling in Dermatology and Onco-dermatology: Current Applications, Future Directions, and Clinical Implications
items: Development of Sustained-Release Aceclofenac Tablets: Optimization of Polymer Matrices for Controlled Drug Delivery
items: Potential Pharmacological Options Against the Coronavirus
items: Recent Therapeutic Approaches for the Management of Diabetes Mellitus
items: EVALUATION OF ANTIVIRAL ACTIVITY AGAINST NEWCASTLE DISEASE VIRUS AND EMBRYOTOXICITY OF ESSENTIAL OIL AND ETHANOLIC EXTRACT OF TRACHYSPERMUM AMMI
items: Evaluation of traditionally claimed anti-ulcerant potential of poly-herbal preparation using rat model
items: Assessment of knowledge, attitude, and Practice (KAP) addressing dengue fever

Assessment of Prevalence, Management and Attitude of dysmenorrhea among University students of Sialkot, Pakistan.
type: item
description: Background: Dysmenorrhea, characterized by painful menstruation, is a highly prevalent gynecological condition that substantially affects the quality of life and academic performance of young women. Objective: This cross-sectional descriptive study aimed to evaluate the prevalence, management strategies, and attitudes towards dysmenorrhea among female university students in Sialkot, Pakistan. Methodology: A structured, validated questionnaire was administered to 450 participants, with 370 responses included in the final analysis. The target population included undergraduate female students aged 18-30 from Imran Idrees College of Pharmacy, Sialkot Medical College, and the University of Sialkot. Results: The findings revealed that 76.1% of respondents experienced dysmenorrhea, with the majority reporting moderate to severe pain. The most common symptoms accompanying dysmenorrhea included fatigue (48.9%), nausea (23.1%), and headache (20.4%), with pain primarily reported in the lower abdomen (56%). Although the majority recognized dysmenorrhea as a normal part of menstruation (58.2%), a significant portion of students (66.6%) believed there is inadequate awareness regarding its management. Management of dysmenorrhea was largely self-directed; 79.6% of respondents did not seek professional medical consultation. Common self-care practices included the use of heating pads (23.4%), rest (22.8%), OTC painkillers (17.9%), and herbal remedies (15.8%). Despite the prevalence of self-medication, only 33.4% found these methods very effective, while the majority (59.5%) rated them as moderately effective. Academic performance and social life were notably impacted by dysmenorrhea, with 59.5% of students reporting impaired academic functioning due to pain, including inability to concentrate and missed classes. However, no significant association was observed between menstrual characteristics and sociodemographic variables such as age or marital status. Conclusion: The study highlig…
subject: Articles
  topic: section
subject: Pharmaceutics
  topic: category
subject: Pharmacology
  topic: category
subject: Dysmenorrhea, prevalence, management, menstrual pain, awareness
  topic: keywords
creator: Fatima Jamil
creator: Alliha Nadeem
creator: Nimra Nasir
creator: Aiman Zahid
creator: Hajra Bibi
creator: Maryam majeed
rights: Copyright (c) 2025 SIST Journal of Pharmacy https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-12-22
publication date: 2025-12-22

CORRELATION OF TRUNK CONTROL AND LOWER LIMB FUNCTIONAL MOBILITY AMONG CHILDREN WITH CEREBRAL PALSY
type: item
description: Background: CP is a non progressive neurological disorder characterized by motor impairments that affect trunk control and lower limb mobility. Effective postural control is essential for functional activities like walking, sitting and transitioning between postures in children with CP. Objective: To evaluate correlation between trunk control and lower limb functional mobility among children with CP. Methodology: A cross sectional study was conducted on 377 children aged 5 to 14 years diagnosed with CP. Trunk control was measured through TCM scale and lower limb functional mobility was assessed using FWT. Results: There was significant positive correlation between trunk control and lower limb functional mobility with strongest correlation between GMFCS level I (r=0.911, p=0.002), level II (r=0.735,p=0.034), Level II (r=0.922, p<0.001) and in ataxic CP (r=0.886), spastic CP (r=0.776), dyskinetic (0.866) and mixed CP (0698). Conclusion: There was positive correlation between trunk control and lower limb functional mobility among children with CP. Children with better trunk control are likely to have higher functional walking ability. Highest impairments were seen in children with spastic CP with GMFCS higher levels.
subject: Articles
  topic: section
subject: Pharmaceutics
  topic: category
subject: trunk control
  topic: keywords
subject: lower limb function
  topic: keywords
subject: CP children
  topic: keywords
subject: functional mobility
  topic: keywords
creator: Gul Andama Gul Andama
creator: Gul Andama N/A
creator: Areeba Ashiq Ali Areeba Ashiq Ali
creator: Kinza Saghir Kinza Saghir
creator: Rameez Ahmed Anjum Rameez Ahmad Anjum
creator: Abdul Rehman Abdul Rehman
creator: Manahil Iqbal Manahil Iqbal
rights: Copyright (c) 2025 SIST Journal of Pharmacy https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-12-22
publication date: 2025-12-22
starting page: 105
ending page: 116

Assessing the Effect of Dietary Practices and Physical Activity on the Health of Pregnant Women
type: item
description: Background: Pregnancy is a period of significant physiological and hormonal changes that increase nutritional demands. Deficiencies, particularly in the first trimester, can lead to restricted fetal growth and have long-term consequences for both mother and child. Furthermore, common pregnancy complications like gestational hypertension and gestational diabetes mellitus (GDM) are linked to adverse outcomes, underscoring the need for proactive management through diet and lifestyle. Objective: The aim of this review is to synthesize the critical role of a balanced diet and structured physical activity in promoting positive maternal and fetal outcomes, preventing common gestational complications, and establishing a foundation for the child's long-term health. Methods: This study is structured as a narrative review, synthesizing established physiological principles and current recommendations for prenatal care. The analysis is based on a consolidation of known best practices regarding maternal nutrition and exercise physiology during pregnancy. Main Outcome Measures: The primary outcomes of interest include the impact of nutrition on fetal development, the prevention of gestational hypertension and GDM, birth outcomes, and the long-term health of the child. For physical activity, the focus is on recommended exercise structure and its benefits for maternal well-being. Results: A balanced diet before and during pregnancy is fundamental for supporting maternal adaptation and preventing complications such as gestational hypertension and GDM, which are associated with risks including pre-eclampsia, fetal growth restriction, preterm birth, macrosomia, and future type 2 diabetes. Adequate and stable nutrition throughout gestation supports appropriate maternal weight gain and is linked to improved delivery outcomes and a reduced risk of the child developing chronic conditions like heart disease and obesity later in life. Conclusion: A well-balanced nutritional intake and regula…
subject: Articles
  topic: section
subject: Pharmacognosy
  topic: category
creator: Irfan Suleheria
creator: Farooq basheer
creator: Hammad Tahir
creator: Fatima Muslim
creator: Hammad Ahmed
rights: Copyright (c) 2025 SIST Journal of Pharmacy https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-12-22
publication date: 2025-12-22
starting page: 19
ending page: 42

Quality and Microbial Assessment of Cooking Oils and Serving Plates Used by Street Food Vendors in District Sialkot, Pakistan
type: item
description: Introduction: Street-vended foods are essential for low- and middle-income populations in developing countries, but public health risks arise from unhygienic practices, including the continual reuse of cooking oil. This study aimed to evaluate the physicochemical quality of cooking oils and the microbial contamination of serving plates used by street food vendors in Sialkot District, Pakistan. Materials and Methods: One hundred and fifty composite samples of frying oils and serving plates were collected from vendors across six zones: urban, educational, kachehri (government offices), bazar (market), fast-food, and rural areas. Oil quality was assessed by analyzing moisture content, free fatty acids (FFA), acid value (AV), peroxide value (PV), and total polar compounds (TPC). Microbial load on serving plates was evaluated using total plate count (TPC) and Escherichia coli enumeration. Results: The highest mean values indicating severe oil degradation were found in samples from rural vendors: FFA (1.82%), AV (3.62 mg KOH/g), PV (13.8 meq/kg), and TPC (28.4%). The bazar area exhibited the poorest hygiene, with the highest mean total plate count (3.7×10⁴ CFU/cm²) and the presence of E. coli on multiple serving plates. Discussion: The results demonstrate significant deterioration of cooking oils, particularly in rural settings, and substantial microbial contamination on serving utensils, especially in market areas. This indicates widespread unsafe practices, including excessive oil reuse and poor hygiene, which pose serious cross-contamination risks to consumers. Conclusion: The findings underscore an urgent need for periodic monitoring of street food operations, strict enforcement of national food safety standards, and targeted awareness programs for vendors and consumers to promote safer food practices in Pakistan.
subject: Articles
  topic: section
subject: Quality Assurance
  topic: category
creator: Aziz ul hassan
creator: Dr. Tahir Nadeem
creator: Afifa Qaisar
creator: Habiba Arooj
creator: Ayesha Noreen
rights: Copyright (c) 2025 SIST Journal of Pharmacy https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-12-22
publication date: 2025-12-22
starting page: 117
ending page: 127

Assessment of Knowledge, Attitude, and Practices about the Management of Medication Errors among Healthcare Professionals in District Sialkot, Pakistan
type: item
description: Introduction: Medication errors are often involved in reported adverse events. Research has revealed the need for improved knowledge in drug dose, dosage form, and medication knowledge, as a whole, is poorly investigated. The purpose of this survey was to study the medication knowledge, certainty, and estimated risk of errors. Methodology: A cross-sectional study was conducted with a validated questionnaire in IITH, IIH Cantt, and different community pharmacies of Sialkot, Punjab, from April to May 2025. The questionnaire consists of four sections. The first contains demographic variables. The second portion assesses the knowledge of HBV infection and its vaccination. The third portion is about the attitude of healthcare workers towards the vaccination, and the last portion evaluates the practice of healthcare workers. To calculate the sample size of the study, the absolute error was estimated to be 5% and a 95% confidence level was used. Result: This study investigated the knowledge, attitudes, and practices regarding medication errors among 150 healthcare professionals in Sialkot, Pakistan. Most participants were aware of medication errors, with a significant proportion familiar with the five rights of medication administration and supportive of error reporting. The primary causes of errors were identified as poor communication, inadequate training, and heavy workloads. Older professionals had a better understanding of administration practices, while doctors and pharmacists showed higher confidence in reporting errors compared to nurses. Access to reporting systems varied by work setting. The study suggests that further training and better communication are essential to reduce errors and improve patient safety. Recommendations include expanding the study to other hospitals and implementing feedback systems. Discussion: Medication errors are a significant concern, with 76% of healthcare professionals experiencing them on a regular basis. Most agree on the importanc…
subject: Articles
  topic: section
subject: Pharmaceutics
  topic: category
creator: Dr. Naima Nasir
creator: Shanza Yousaf
creator: Faria Shahzadi
creator: Fatima Rasool
creator: Samra Asif
creator: Khizra Nawazish
rights: Copyright (c) 2025 SIST Journal of Pharmacy https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-12-22
publication date: 2025-12-22
starting page: 89
ending page: 104

Exploring the Role of Microneedling in Dermatology and Onco-dermatology: Current Applications, Future Directions, and Clinical Implications
type: item
description: Background: Microneedling (MN) is an innovative therapeutic technique that has gained significant prominence over the last decade. It functions by inducing controlled physical trauma via needle penetration, which activates the skin's natural wound healing processes with minimal damage to the epidermis. A key ancillary benefit is its ability to significantly enhance the transdermal absorption of topically applied medications, making it a versatile tool for dermatological treatment. Objective: This review aims to synthesize and evaluate the current applications of microneedling within dermatology, with a specific focus on its use for treating various skin conditions and neoplasms. A further objective is to discuss the future prospects and necessary directions for research to optimize this technology. Methods: This study is structured as a comprehensive narrative review, analyzing and consolidating findings from existing literature on the clinical use of microneedling. The analysis encompasses its use both as a standalone procedure and in combination with topical therapeutics. Main Outcome Measures: The primary outcomes assessed were the efficacy of MN in treating specific dermatological diseases and its role in enhancing drug delivery. Secondary outcomes included an evaluation of its advantages and the identification of optimal parameters for clinical use. Results: The review confirms that microneedling has been successfully employed to manage a wide spectrum of conditions, including psoriasis, atopic dermatitis, viral warts, scars, alopecia, pigmentation disorders, and skin tumors. Its hallmark advantages are a reduction in systemic adverse drug effects and a favorable safety profile. However, the literature reveals a lack of consensus on optimal device settings, treatment frequency, and intervals. Conclusion: Microneedling represents a highly promising and minimally invasive modality in dermatology. While current evidence supports its efficacy for diverse conditions…
subject: Articles
  topic: section
subject: Pharmacology
  topic: category
subject: Dermatology
  topic: keywords
subject: Cancer
  topic: keywords
subject: Skin cancer
  topic: keywords
creator: faiza Rafique
creator: Sameer Iqbal
creator: Hammad Ahmed
creator: Muhammad Farooq
creator: Sharjeel Adnan
rights: Copyright (c) 2025 SIST Journal of Pharmacy https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-12-22
publication date: 2025-12-22
starting page: 128
ending page: 149

Development of Sustained-Release Aceclofenac Tablets: Optimization of Polymer Matrices for Controlled Drug Delivery
type: item
description: Background: Aceclofenac is a widely used non-steroidal anti-inflammatory drug requiring frequent administration, making it a suitable candidate for a sustained-release formulation to improve patient compliance. Objective: This study aimed to formulate and evaluate sustained-release tablets of Aceclofenac using different polymer matrices to achieve a prolonged drug release profile. Methods: Tablets were formulated with varying concentrations of Carbopol, Kollidon SR, Eudragit L100, and their combinations using the wet granulation technique. The prepared granules were evaluated for flow properties (bulk density, tapped density, Hausner ratio, Carr's index, angle of repose). The resulting tablets were assessed for thickness, hardness, friability, weight variation, and content uniformity. In vitro drug release studies were conducted for 12 hours in 0.1 N KOH and phosphate buffer (pH 6.8) using USP apparatus II, and the drug release data were fitted to various kinetic models. Main Outcome: The primary outcomes were the physicochemical properties of the granules and tablets, and the drug release kinetics from the formulated matrix systems. Results: All formulated granules demonstrated acceptable flow properties, and the tablets complied with official limits for evaluated physicochemical parameters. The drug release from the optimized formulation U18 (Kollidon SR with Eudragit L100) best fitted the Higuchi model, while formulation U20 (Kollidon SR with Carbopol) followed zero-order release kinetics. Conclusion: The study successfully developed sustained-release Aceclofenac tablets. The optimized formulations U18 and U20, based on their distinct release kinetics, were identified as suitable matrix systems for providing sustained drug release
subject: Articles
  topic: section
subject: Pharmaceutics
  topic: category
creator: Rizwan Khan
creator: Ali Shareef
creator: Muhammad Ijaz
rights: Copyright (c) 2025 SIST Journal of Pharmacy https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-12-22
publication date: 2025-12-22
starting page: 65
ending page: 88

Potential Pharmacological Options Against the Coronavirus
type: item
description: Background: The emergence of the novel coronavirus (2019-nCoV) and the resulting COVID-19 disease initiated a global pandemic, threatening human lives and societies on an unprecedented scale. While three previous coronavirus epidemics have been documented, the 2019 outbreak distinguished itself through its rapid global spread and multifaceted transmission pathways, swiftly escalating into a worldwide health emergency. Objective: This study aimed to analyze previous coronavirus epidemics by comparing their outcomes with the recent COVID-19 pandemic. A further objective was to discuss pharmacological agents demonstrating potential in-vitro and in-vivo activity against the virus, with a critical focus on the evidence for remdesivir and chloroquine. Methods: A comparative analysis was conducted, evaluating the epidemiological trajectories and outcomes of previous coronavirus outbreaks against the COVID-19 pandemic. Additionally, a review of scientific literature was performed to identify and assess pharmacological agents with reported anti-COVID-19 activity in both laboratory and animal studies. Main Outcome Measures: The primary outcomes were the comparative transmissibility and scale of the COVID-19 pandemic relative to previous coronavirus epidemics, and the summarized preclinical evidence for the efficacy of selected pharmacological agents. Results: The analysis confirmed that the COVID-19 pandemic spread more rapidly and extensively than previous coronavirus epidemics. The review identified several agents with promising in-vitro and in-vivo activity. However, the capacity of remdesivir and chloroquine for treatment and prevention remains a subject of intense debate, underpinned by premature findings, a lack of robust clinical trials, and significant concerns regarding long-term safety. Conclusion: The COVID-19 pandemic represents a significant escalation in the threat posed by coronaviruses. While certain drugs show preclinical promise, the evidence for their clini…
subject: Articles
  topic: section
subject: Pharmaceutics
  topic: category
creator: Muhammad Ijaz
creator: Fawad Ahmed
creator: Jawad Ahmed
creator: Ghulam Murtaza
creator: Muhammad Ihtisham Umer
creator: Waseem Hassan
rights: Copyright (c) 2025 SIST Journal of Pharmacy https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-12-22
publication date: 2025-12-22
starting page: 169
ending page: 182

Recent Therapeutic Approaches for the Management of Diabetes Mellitus
type: item
description: Background: Diabetes mellitus (DM) is a global epidemic with a prevalence anticipated to double in the next decade, placing a heavy burden on healthcare systems. While current treatments like metformin, secretagogues, thiazolidinediones, and insulin are useful, there is a pressing need for novel medications that not only achieve customized glycemic objectives but also address concurrent comorbidities and maximize safety. Objective: This review aims to focus specifically on the highly anticipated and recognized novel pharmacological approaches currently in the clinical pipeline for diabetes mellitus. It seeks to identify and evaluate these approaches based on growing incidental evidence and their potential to shift the treatment paradigm from management to cure. Methods: A narrative review of the current clinical pipeline was conducted, focusing on agents identified through global studies and growing incidental evidence. The approaches highlighted were selected based on their novel modes of action and significant recognition within the development landscape. Main Outcome: The primary outcomes of interest include the efficacy of novel approaches in maintaining optimum glucose levels, their mechanisms of action (e.g., improving insulin sensitivity, increasing insulin secretion, modulating the incretin axis, decreasing hepatic glucose synthesis), and their potential to address comorbidities and avoid complications. Results: The pharmacological pipeline for DM is rich with promising approaches. The approval of SGLT2 inhibitors like canagliflozin, dapagliflozin, and empagliflozin has laid the foundation for a new era in treatment. Current clinical developments are characterized by drugs utilizing new modes of action that go beyond traditional glycemic control, showing significant potential for improved efficacy and non-glycemic benefits. Conclusion: The development of novel DM medications is highly encouraging, raising the bar for future therapies. The evolving pipeline, …
subject: Articles
  topic: section
subject: Pharmaceutics
  topic: category
subject: Pharmacology
  topic: category
creator: waseem hassan
creator: Faraza Javaid
creator: Hafiza Maida Arshad
creator: Ambreen Mehmood Awan
creator: Wafa Majeed
rights: Copyright (c) 2025 SIST Journal of Pharmacy https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-12-22
publication date: 2025-12-22
starting page: 150
ending page: 168

EVALUATION OF ANTIVIRAL ACTIVITY AGAINST NEWCASTLE DISEASE VIRUS AND EMBRYOTOXICITY OF ESSENTIAL OIL AND ETHANOLIC EXTRACT OF TRACHYSPERMUM AMMI
type: item
description: Background: Trachyspermum ammi (Ajwain) is a medicinal plant known for its therapeutic properties. Given its bioactivity, it presents a promising candidate for treating viral diseases such as Newcastle disease, a highly contagious and economically significant viral illness of poultry caused by the Newcastle disease virus (NDV). Objective: The present study aimed to evaluate the antiviral activity and embryo toxicity of the essential oil and ethanolic extract of T. ammi against NDV using an in ovo model. Methods: Ten serial dilutions (100 to 0.19 µg/mL) of both T. ammi essential oil and ethanolic extract, and five concentrations (40 to 20 µg/mL) of the standard antiviral drug ribavirin were prepared. Each concentration was mixed with a fixed titer (4 HA units) of virulent NDV. The mixtures were inoculated into nine-day-old specific pathogen-free (SPF) chicken embryos, which were then incubated for 72 hours. Antiviral activity was assessed post-incubation using a hemagglutination test, while embryo toxicity was calculated based on the percentage of embryo survival. Main Outcome Measures: The primary outcomes were the minimum concentration of each substance that achieved complete inactivation of NDV (antiviral activity) and the concentration at which embryo mortality occurred (embryo toxicity). Results: The essential oil of T. ammi demonstrated complete inactivation of NDV across a wide concentration range, from 0.78 µg/mL to 100 µg/mL. The ethanolic extract of T. ammi showed complete antiviral activity from 1.5 µg/mL to 100 µg/mL. The Embryo toxicity for both the essential oil and the ethanolic extract was observed only at the highest tested concentration of 100 µg/mL. Ribavirin exhibited strong antiviral activity at all tested concentrations (20-40 µg/mL) but was found to be embryo-toxic at the higher concentrations of 40, 30, and 25 µg/mL. Conclusion: This experiment demonstrates that both the essential oil and ethanolic extract of Trachyspermum ammi possess signifi…
subject: Articles
  topic: section
subject: Pharmacognosy
  topic: category
subject: Pharmacy Practice
  topic: category
creator: Mueen Ahmad Chaudhry
creator: Muhammad Farooq
creator: Iqra Mubeen
rights: Copyright (c) 2025 SIST Journal of Pharmacy https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-12-22
publication date: 2025-12-22
starting page: 11
ending page: 18

Evaluation of traditionally claimed anti-ulcerant potential of poly-herbal preparation using rat model
type: item
description: Background: Despite the proven effectiveness of many traditional polyherbal medicines, their scientific mechanisms of action often remain unclear. Qarahine is one such compound preparation, and its purported therapeutic benefits for ulcer treatment require empirical validation to understand its rationale. Objective: This study was conducted to validate the anti-ulcer effect of the polyherbal preparation Qarahine through integrated in-vivo and in-vitro studies, specifically measuring its ulcer-curative potential and assessing its effectiveness against duodenal ulcers. Methods: The anti-ulcer activity was evaluated in vivo using rodent models of ethanol-induced, NSAID-induced, and stress-induced gastric ulcers at two dose levels (50 and 100 mg/kg). Histopathological examination of stomach tissues provided supporting evidence. The in-vitro spasmolytic effect was assessed on isolated rabbit jejunum preparations, testing the crude extract on spontaneous, high K+ (80 mM)-induced, and carbachol (1 µM)-induced contractions, with verapamil used as a standard reference. Main Outcome Measures: The primary outcomes were the percentage cure of induced ulcers in the different models and the concentration-dependent spasmolytic response in the isolated tissue experiments. Results: Qarahine demonstrated significant, dose-dependent anti-ulcer activity. It cured 31.1% and 60% of ethanol-induced ulcers, 46.7% and 86.7% of NSAID-induced ulcers, and 33.3% and 76.3% of stress-induced ulcers at doses of 50 and 100 mg/kg, respectively. Histopathological analysis strongly corroborated these findings. In vitro, the extract exhibited a concentration-dependent spasmolytic effect, inhibiting contractions induced by high K+ and carbachol, similar to the calcium channel blocker verapamil, suggesting a potential mechanism involving calcium channel blockade. Conclusion: The results of the present study provide robust scientific evidence for the anti-ulcer efficacy of Qarahine. Based on these finding…
subject: Articles
  topic: section
subject: Pharmaceutics
  topic: category
subject: Pharmacology
  topic: category
creator: Hammad Ahmed
creator: Mueen Ahmad Chaudhry
creator: Mahtab Ahmad
creator: Sharjeel Adnan
rights: Copyright (c) 2025 SIST Journal of Pharmacy https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-12-22
publication date: 2025-12-22
starting page: 1
ending page: 10

Assessment of knowledge, attitude, and Practice (KAP) addressing dengue fever
type: item
description: Background: Dengue is the most common illness borne by mosquitoes. Aims: The main aim and goal of this research was to assess the current knowledge, attitude, and strategies addressing fever caused by mosquitoes, and its prevalence among the local community of Karachi. Methods: This study was conducted from January 2025 to March 2025 among the community of Karachi. The data was collected by using the proper self-constructed questionnaire method. SPSS version 25.0 statistical techniques were used to analyze the obtained data. Results: Data of 350 responses were selected for this survey base research and the average age of the respondents were 25-60 years of age and of theses, 79.6% of the responders were between the age of 15 and 40. Approximately 86.90% of respondents were aware of mosquitoes, viral infections, and dengue fever, and 69.40% had knowledge of the role and participation of the community in the prevention of these diseases.. Conclusion: Regular efforts are desperately needed in local communities, schools, and colleges to raise awareness of dengue fever, its transmission, and preventative measures.
subject: Articles
  topic: section
subject: Pharmacology
  topic: category
subject: Pharmacy Practice
  topic: category
subject: Attitude, Dengue Fever, Knowledge, Practice
  topic: keywords
creator: Shaheen-Ul-Islam
creator: Muhammad Ali
creator: Khawaja Atif Naseeb
creator: Asma kousar
rights: Copyright (c) 2025 SIST Journal of Pharmacy https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-12-22
publication date: 2025-12-22
starting page: 43
ending page: 64