Exploring the Psychological Impact of Generalized Pain: The Role of Anxiety, Depression, and Social Support

Authors

  • Khizra Hameed Salim Habib University image/svg+xml Author
  • Saba Razzak Department of Pharmacy Practice and Pharmaceutical Chemistry, Faculty of Pharmacy, Salim Habib University Karachi, Pakistan. Author
  • Muhammad Ali Department of Pharmaceutics, Faculty of Pharmacy, Salim Habib University, Karachi, Pakistan. , Department of Pharmacy Practice, Faculty of Pharmacy, Salim Habib University, Karachi, Pakistan. Author
  • Syeda Sameen Zehra Department of Pharmacy Practice and Pharmaceutical Chemistry, Faculty of Pharmacy, Salim Habib University Karachi, Pakistan. Author
  • Fatima Jawaid Department of Pharmacy Practice and Pharmaceutical Chemistry, Faculty of Pharmacy, Salim Habib University Karachi, Pakistan. Author
  • Arifa Hussain Department of Pharmacy Practice and Pharmaceutical Chemistry, Faculty of Pharmacy, Salim Habib University Karachi, Pakistan. Author

Keywords:

Generalized pain, psychological distress, anxiety, depression, social support

Abstract

Abstract

Background: Persistent pain, whether acute or chronic, often has profound psychological consequences, commonly manifesting as anxiety and depression. Generalized pain, in particular, poses diagnostic and therapeutic challenges due to its non-specific nature. While numerous studies have assessed pain's impact on mental health, the moderating effect of social support remains underexplored.

Objective: This study investigates the link between generalized pain and psychological distress, specifically focusing on anxiety and depression, and evaluates the potential buffering role of perceived social support.

Methods: A cross-sectional survey was administered to 70 individuals experiencing generalized pain. Standardized instruments including the Brief Pain Inventory (BPI), Hospital Anxiety and Depression Scale (HADS), and Multidimensional Scale of Perceived Social Support (MSPSS) were employed. Data were analyzed using correlation and regression techniques to determine significant associations.

Results: Individuals experiencing continuous pain exhibited elevated levels of psychological distress compared to those with intermittent pain. Regression analysis identified pain severity and avoidance behaviors as significant predictors of distress, explaining 46% of the variance. Although social support was negatively correlated with distress, it did not significantly predict psychological outcomes.

Conclusion: The findings underscore the critical role of pain-related avoidance and intensity in mental health outcomes. Social support, while related to lower distress levels, did not emerge as a significant predictor. Interventions targeting avoidance behavior and integrating social support structures may enhance pain management strategies.

SIST JOURNAL OF PHARMACY

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Published

2026-03-04

How to Cite

Exploring the Psychological Impact of Generalized Pain: The Role of Anxiety, Depression, and Social Support. (2026). SIST Journal of Pharmacy, 2(1). https://journals.sialscribe.com/index.php/SJP/article/view/27

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