PELLETIZATION TECHNIQUES AND EXTRUSION- SPHERONIZATION: A REVIEW

Abstract

Oral multiparticulate drug delivery system offers better biopharmaceutical advantage as compared to single unit oral dosage form. Pelletization technique helps in the formation of spherical beads or pellets with mean diameter of 0.5- 2 um. Pellets can be coated for enhancement of flow and mixing properties which ultimately reduces segregation and improving physical and chemical properties of fine powder. Different techniques such as Extrusion-Spheronization, drug layering, cryopelletization, hot melt extrusion, spray drying, spray congealing and freeze drying are successfully discussed in this review. Simple and fast processing and high efficiency obtaining properties made Extrusion-Spheronization technique superior as compare to others. The characterization, evaluation and importance of pellets with its affecting parameters will also discuss.